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Nat Metab 6:343358 Nakamura T, Conrad M (2024) Exploiting ferroptosis vulnerabilities in cancer

Its unique -glutamyl linkage rather than the standard -peptide bond between Glu and Cys confers resistance to most peptidases and extends its intracellular half-life substantially

They are typically administered via subcutaneous injection, though some may be available in oral, nasal, or topical forms

Other rHDL preparations have included the 5A peptide and have shown promising results in animal models by triggering plaque regression (Schwendeman et al., 2015

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