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Investigating VPA toxicokinetics and concentration/effect relationships may help understanding how to improve VPA-poisoned patient management

Previous studies have revealed that PIK3CA mutations reprogram glutamine metabolism by upregulating the expression of glutamate pyruvate transaminase (GPT) 2, thereby increasing glutamine dependency in CRC cells [101]

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There are also no published guidelines for appropriate dosing regimes, or guidance for treatment duration when using this agent in this setting." There is unknown validity and some known adverse effects with IV GSH

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