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Nonsteroidal anti-inflammatory drugs (NSAIDs) such as high-dose aspirin or indomethacin have been reported to alter GH release in some contexts, though this is more pertinent to GH stimulation testing than chronic therapy

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Correcting metabolic acidosis with sodium bicarbonate directly inhibits the activation of UPS and autophagy pathways by an acidic environment, reduces branched-chain amino acid breakdown, and creates a favorable internal environment for muscle synthesis (110, 111)