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In our opinion, further carefully designed studies are still necessary for substantiating this view and supporting optimum procedures in terms of both efficacy and safety profiles

Consistently, Reactome (REAC) analysis revealed that CHL-upregulated proteins were significantly enriched in the innate immune system ( p adjusted = 3.1E-12), complement cascade ( p adjusted = 6.6E-07) and antimicrobial peptides ( p adjusted = 3.5E-08)