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Intersection analysis identified seven potential targets linking selenium to brain aging, from which machine-learning feature selection prioritized three core genes (SP1, SEPHS2, and MSRB1) that were significantly differentially expressed in aged samples

Gier EC, Pulliam AN, Gaul DA, Moore SG, LaPlaca MC, Fernndez FM

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Materials and methods Materials ASX, recombinant human Lf, 1,2-dioleoyl- sn -glycero-3-phosphocholine (DOPC), cholesterol, lipopolysaccharide (LPS), modified Griess reagent, and selegiline hydrochloride were bought from Sigma-Aldrich (St