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10.1007/s00586-020-06446-z 363 RasaS.Nora-KrukleZ.HenningN.EliassenE.ShikovaE.HarrerT.et al (2018)

If the ferrous heme (Fe 2+ ) iron contained in the prosthetic group of Hb is oxidized to ferric (Fe 3+ ) heme to form methemoglobin (metHb), the affinity of the protein toward oxygen is dramatically decreased

fumigatus is a thermophilic fungus able to grow at 55C and survive at more than 75C,26,241 an essential ability to thrive in decaying organic matter and to infect mammalian hosts

Recent pioneering research by Wang et al

While headaches, nausea, vomiting, diarrhea, reduced appetite, skin rashes, and hot flushes are common side effects, consulting a medical professional if these worsen is advisable