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Inflammatory signaling is intricately linked with oxidative stress, where DAMPs released from injured ovarian cells activate TLR4 and downstream NF-B and NLRP3 inflammasome pathways

In recent years, epidemiological and translational medicine research has continually revealed how air pollution, heavy metals, and various chemicals affect gut health through multiple mechanisms, promoting the onset and exacerbation of IBD

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Synkinesis is defined as an abnormal involuntary facial movement occurring with the voluntary movement of a different facial muscle group [3]