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A novel immunoconjugate compound, L-DOS47, was utilized to increase the pH of an acidic medium in vitro to evaluate its effects on Jurkat, a human T lymphoblast-like cell line

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In addition, to evaluate the advantages of TAP-VK1 ( 2a ) as the novel compact fluorophore (5 + 5 membered ring), commonly used small molecular fluorophores such as coumarin ( 8 ) (6 + 6 membered ring), NBD ( 9 ) (6 + 5 membered ring), and ABD ( 10 ) (6 + 5 membered ring) were similarly introduced into the thiol group of captopril to give captopril-coumarin ( 8o ), captopril-NBD ( 9o ), and captopril-ABD ( 10o ), respectively (Supplementary Table 4)