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The AHEAD model achieved an AUC of 0.695 (95% CI 0.6080.782), demonstrating superior performance compared to the NIAAA model, which had an AUC of 0.590 (95% CI 0.4940.685) (Bootstrap p = 0.049)

First, in the extrinsic pathway xenobiotics interact with so-called death receptors ( e.g ., Fas, also called Apo-1 or CD95) or tumor-necrosis factor receptor, TNF-R) to cause activation of the death-inducing signaling complex (DISC)

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Cancers (2020) 12(4):812

Nanoparticle conjugation of ginsenoside Rg3 inhibits hepatocellular carcinoma development and metastasis