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In breast cancer, CBD reduces cell proliferation and induces apoptosis through the TRPV1 and PPAR- pathways, while also disrupting mitochondrial function, leading to cell death [174,176]

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doi: 10.1007/s13346-022-01137-2 165 PatelNKommineniNSurapaneniSKKalvalaAYaunXGebeyehuAet al

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We identified programmed cell death protein 5 (PDCD5) as a target gene of Lgr5 and we found that PDCD5 was responsible for Lgr5-mediated Dox resistance