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Finally, we also proposed to make conforming revisions to 180.90(d)(1) and to add a new 180.90(d)(2) to take into account the proposed provisions at 180.90(c)(4), which would allow for a reduction to the CMP amount were certain criteria to be met, as discussed above

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The Interplay of Oxidative Stress and Cobalamin in MS Management Oxidative stress, characterized by a discrepancy between the formation of reactive oxygen species (ROS) and the ability of antioxidant defenses to neutralize them, has been linked to the pathophysiology of MS by inducing inflammation, demyelination, and neurodegeneration [109]