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Description

Researchers examine how NNMT inhibition affects NAD+ levels, sirtuin activity, mitochondrial efficiency, glucose/lipid metabolism, and metabolic parameters in experimental systems focused on aging and metabolic disorders

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Inhibition of mitochondrial pyruvate dehydrogenase kinase: a proposed mechanism by which melatonin causes cancer cells to overcome cytosolic glycolysis, reduce tumor biomass and reverse insensitivity to chemotherapy

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