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Injectable protocols may allow longer continuous use due to more predictable blood levels, while oral protocols might benefit from periodic breaks to maintain absorption efficiency

Missing doses or altering the schedule without medical advice can impact the effectiveness of the therapy and potentially increase side effects

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A relationship between vitamin C deficiency and gallstones has been recognized since the 1970s (Ginter 1971) and, for decades, low intake has been implicated in raising cholesterol saturation in the bile and in increasing the likelihood of gallstone formation (Simon 1993