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In some embodiments, the term alkylene may include (CH 2 )n- where n is 2-8

A key protein in axonal transport is Stathmin 2 (STMN2), which aids in axonal regrowth after injury and is found to be altered specifically by the toxic accumulations of TDP-43 and is found in lower quantities in spinal cords of mouse models of ALS [202, 287]