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Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells

The respiratory burst in neutrophils is characterized by an elevated production of the superoxide anion radical (O 2 ), a principal ROS generated in response to external stimuli, e.g., inflammation ( In the context of atherosclerosis, various factors can induce the respiratory burst, including pro-inflammatory cytokines, lipids such as cholesterol, oxLDL, acute phase proteins like CRP, growth factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF), circulating immune complexes, and others (Kannan et al., 2007)

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Hsu YS, Wu PJ, Jeng YM, Hu CM, Lee WH

Previous studies revealed that the polysaccharides of BP (Chinese wolfberry) have immunomodulatory activity in vitro against RAW 264.7 cells via downregulating the level of tumor necrosis factor-alpha (TNF-), interlukin-1 (IL-1), interlukin-6 (IL-6), and nitric oxide (NO) secretion (162)