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These findings allowed to stratify early psychosis patients in two subgroups: (a) patients with mitochondrial dysfunction characterized by exosomal high miR-137 and low COX6A2, presumably representing PV neuron dysfunction associated with mitochondria and (b) patients without mitochondrial dysfunction having miR-137 and COX6A2 levels within the healthy control range

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By exploiting improvements in techniques for the isolation of intact spinach chloroplasts that retain the chloroplast envelope and therefore stromal components (as well as the thylakoid membranes), the authors were able to locate appreciable GR activity and contents of glutathione in this organelle

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