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Background Information Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts

Gilbert NC, Newcomer ME, Werz O

doi:10.1038/nature13955 33

The idea behind this is that the two proteins target different steps of the regeneration process, one being migration and mobilization of the cytoskeleton, and the other one being vascularization and cytoprotection