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In older age, vitamin B12 absorption tends to be less efficient due to a range of health issues, including gastritis stomach lining inflammation and thinning but also because of decreased production of stomach secretions (EFSA, 2015

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For instance, when excluding both supplements and medications, those with a deficient-low B 12 status had a significantly increased risk of incident depressive symptoms (OR 165 (95 % CI 107, 254)