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KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease

We observed that increased lysis resulted from oxidative damage to the erythrocyte membrane, causing a decrease in membrane fluidity and reducing its ability to withstand osmotic changes, and intracellular glutathione was more oxidized in erythrocytes from preeclamptic women as compared to normotensive primiparae

After alkylation, all samples were diluted (1:1) with 20% ACN/0.1% FA containing 50 nM of deuterated internal standards

Dosing Example: To get that same 1mg dose, you would now draw 0.2 mL (or 20 units)