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Reduced hepatic eNOS phosphorylation is associated with NAFLD and type 2 diabetes progression and is prevented by daily exercise in hyperphagic OLETF rats

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity

For example, activated IRE1 and recruited TRAF2 activate JNK, inducing the production of IL-6 and TNF- by phosphorylation of AP-1 and consequent NF-B activation

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We find that the cancer-related truncated variants comprising residues 1-645 and 1-591 of ASXL1 (ASXL1 1-645 and ASXL1 1-591 ) retain BRD4 binding function, with ASXL1 1-645 showing an enhanced ability to recruit BRD4 to promoters of ASXL1 target genes