Abbreviations %: Percentage m: Micrometer ADA: American Diabetes Association ALO: Aloperine ATP: Adenosine triphosphate cAMP: Cyclic adenosine monophosphate CRP: C-reactive protein DKA: Diabetic ketoacidosis DM: Diabetes mellitus DPP-IV: Dipeptidyl peptidase-IV GAD: Glutamic acid decarboxylase GLP-1: Glucagon-like peptide-1 GLUT-4: Glucose transporter type 4 GPx: Glutathione peroxidase GSH: Glutathione HDL: High-density lipoprotein IL-1: Interleukin 1 IRS-2: Insulin receptor substrate-2 LDL: Low-density lipoprotein MAMs: Mitochondria-associated membranes NIDDM: Non-insulin dependent diabetes mellitus nm: Nanometer OS: Oxidative stress PDX-1: Pancreatic and duodenal homeobox-1 PI3K: Phosphatidylinositol 3-kinase PKC: Protein kinase C PPAR-: Peroxisome proliferator-activated receptor- ROS: Reactive oxygen species SOD: Superoxide dismutases STZ: Streptozotocin T1DM: Type 1 diabetes mellitus T2DM: Type 2 diabetes mellitus TNF: Tumour necrosis factor-alpha References Ojo OA, Ibrahim HS, Rotimi DE, Ogunlakin AD, Ojo AB
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10.1016/j.neuroimage.2014.11.032 167 Snchez-RodrguezI.Temprano-CarazoS.NjeraA.DjebariS.YajeyaJ.GruartA.et al
found that metformin inhibits the palmitic acid (PA)-induced upregulation of periostin (POSTN), which in turn increases p53 expression in VSMCs
To investigate this phenomenon, Kriss and colleagues [13] studied the effect of ethanol metabolism on histone acetylation in mouse liver using 13 C 2 -labeled ethanol and mass spectrometry
The study was approved by the Ethics Committee (52237915.5.0000.5013), and ethical considerations were based on the use of the material for scientific purposes, with the confidentiality of the patient identity and without constraint from the institutions or people involved