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doi: 10.1073/pnas.0810199105 161 RoncaRGhediniGCMaccarinelliFSaccoALocatelliSLFoglioEet al

Spermidine trihydrochloride was non-genotoxic in the in vitro assays, and no adverse effects were reported in the 90-day oral (dietary) toxicity study up to the highest dose tested, which was 728 mg/kg bw/day for males and 829 mg/kg bw/day for female rats 132