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Description

Fitness Integration: Injectable glutathione complements exercise training by supporting antioxidant defenses during periods of increased oxidative stress while allowing for the hormetic benefits of exercise-induced oxidative challenge

doi: 10.1016/S0378-1119(97)00105-4

The 22-nt long mature miRNA strand obtained from the intermediate duplex is then loaded into the Argonaute-containing RNA-induced silencing complex (RISC) and target mRNA molecules by miRNA:mRNA sequence complementarity and negatively affects gene expression either through mRNA cleavage and degradation via the perfect base-pairing with target mRNA or translation repression via imperfect complementation with 3UTR of target mRNA (Smith-Vikos and Slack, 2012)