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Using Ribonuclease A as model protein we show that inclusion of diMESNA during intein-mediated cleavage results in simultaneous on column refolding and thioester formation, providing a novel method for the production of correctly folded, disulfide-bridge containing proteins with a C-terminal thioester suitable for native chemical ligation

A B12 anemic model in immunocompromised and immunocompetent mice, demonstrates improved survival, and lower bacteria in organs, in B12 anemic animals infected with Mtb relative to non-anemic controls

Sulfur Metabolism in Phototrophic Organisms, pp

Methodologically, employing randomized controlled trials with high evidentiary standards, longitudinal cohort studies, and umbrella platform trial designs is recommended

Further GUSAR software was utilized to estimate LD 50 values in rats via oral, intravenous, intraperitoneal, and subcutaneous routes