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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)

The expressed GST genes are distributed across various classes, with a particularly strong representation of the theta class ( GSTT3, n = 41 , Supplementary Dataset 1 )

These finding highlights the potential of stress management in treating abdominal pain in IBS-C

Chronic stress, poor sleep, heavy alcohol use, and UV exposure all accelerate depletion

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