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However, the cGAS-STING pathway are frequently inactivated in tumors, as it is a strategy employed by cancer cells to evade immune surveillance and promote tumor progression

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Diabetes 58 , 773795 (2009)

It is a serious clinical problem associated with high mortality, especially among patients hospitalized in intensive care units and with weakened immunity (Sakr et al., 2018)

In addition, systemic ferroptosis induction affects both cancer cells and immune cells, and its therapeutic effect on overall tumor growth remains uncertain