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doi: ..10.1046/j.1523-1755.1998.00781.x [PubMed: 9461106] [CrossRef] 83

It is possible that iron overload and iron-mediated free radical production cause the loss of TJs proteins and degeneration of endothelial cells, and that targeting iron mediated oxidative stress provides an extended therapeutic time window against an ischemic event (Park et al., 2011