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However, taking periodic breaks (2-4 weeks off after each cycle) may help maintain effectiveness and prevent potential tolerance

Istradefylline also improved UPDRS Part III scores during the ON phase at both doses, with a stronger effect at 40 mg/day (SMD = -0.24, 95% CI = -0.37 to -0.11, p = 0.0002) than at 20 mg/day (SMD = -0.15, 95% CI = -0.27 to -0.02, p = 0.02)

Conclusion and perspective The cancer-associated microbiota is integral to the tumor ecosystem and is significantly involved in tumor progression, metabolism, and the immune response