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The theory is that carnitine boosts the efficiency of neuronal energy metabolism, helping aged brain cells generate ATP more effectively from fatty acids

its metabolites also cause DNA damage and mutations in bladder epithelial cells (Mastrangelo et al., 1996)

Therefore, ME2 has two functions in mitochondria: the first is producing pyruvate and NADH to generate ATP through oxidative phosphorylation, and the second is generating NADPH to counteract ROS

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After quality control, pre- and post-treatment measurements of IC/VC VOIs were available for 52/53 and 46/53 patients, respectively, whereas data at both time points were available for 43/50 patients