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Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis

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Each sample was thereafter incubated with 10 l of acetonitrile and stored at 20 C before analysis was performed on a Beckman HPLC instrument operated with System Gold coupled to diode array UVVIS detector module 168

The overarching aim is to synthesize current knowledge and propose a bioavailability-oriented framework for modern TCM quality control, capable of ensuring predictable clinical efficacy and controllable quality risks by bridging the critical gap between chemical composition and biological response

Healthcare strategies to combat PASC, the novel virus-induced human metabolic syndrome, requires an in-depth understanding of the following: (i) the genomic and metabolomic (proteomic/lipidomic) signatures of SARS-CoV-2 and their interactions with host cellular metabolic machinery, (ii) the virus-induced HMRD and resulting pathophysiological manifestations in the onset and progression of COVID-19, (iii) the cumulative role of HMRD, symptomatic outcomes (disease spectrum), and comorbidities in systemic/multi-organ dysfunction during COVID-19, (iv) both virus- and host-mediated factors that contribute to transition of acute SARS-CoV-2 infection (COVID-19) into a persistent chronic state of virus-free PASC, (v) protracted effects of HMRD in tandem with patients history, in the development of new onset metabolic syndromes (i.e., T2DM, CVD, ME/CFS and POTS) among PASC patients, (vi) stratification/categorization of PASC patients based on persistent symptoms, organ/system involvement, and metabolic dysfunction for specific target-delivered health recovery regimens, and (vii) the structure-function activity of specific bio-functional dietary compounds in formulating precision nutrition protocols to reset SARS-CoV-2-induced HMRD in chronic PASC