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Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome

R 8 , R 8a , R 8b are independently selected from the group consisting of H

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Nicotinamide analogs such as 6-methylaminonicotinamide form one class of NNMT inhibitors that work by mimicking the natural substrate, NAM, and competing for the enzymes active site 197