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The results if extrapolatable in case of -synuclein will imply that oligomers of -synuclein formed in the presence of zinc are also transient unstable entities not capable of inducing pores in lipid membranes

4 Ferroptosis defense systems 4.1 SLC7A11-GSH-GPX4 axis The main barrier that inhibits the path of ferroptosis is the redox of the cell, which is that it can instantly remove membrane phospholipid peroxide

607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

As a result, Hippo pathway like ubiquitination and phosphorylation of YAP are strengthened [130]