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These cells did not grow in medium without any glutathione (0 M) but they grew in media with very small amounts of glutathione (i.e., more than 0.25 M of extracellular glutathione)

however, the 5-year survival rate for patients with advanced OC remains low (49%, 2022) due to tumor heterogeneity, lack of reliable early diagnostic methods and the high incidence of chemotherapy resistance

10.1038/nature19949 3 AngW

246 These different results suggest that in-depth mechanistic research, such as the study of the effects of oxidative stress on DNMT enzyme activity, transcription, protein stability, and redox modification patterns, will help researchers understand the different biological functions of oxidative stress and develop new treatment strategies