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CD20-selective inhibition of CD47-SIRP "don't eat me" signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab

This is particularly important for injuries in low-blood-flow areas like tendons and ligaments

Given that the phase-response curve differs by the dosage, high doses of melatonin may not be beneficial to advance the melatonin rhythm

Gregory Lubiniecki, vice president of oncology clinical research at Merck Research Laboratories, noted in a statement that prognoses are generally poor for this disease and said the company is pleased to offer a new first-line treatment option. The approval was backed by results from the Phase II/III KEYNOTE-483 trial, where Keytruda elicited a significant survival benefit for patients, cutting the risk of death by 21%