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Rampant oxidative stress resulting from glutathione insufficiency may contribute to the pathogenesis of several neurological and neurodegenerative disorders, type 2 diabetes, cancer, heart attack and stroke.45 Supplementation may be warranted in order to correct depleted states and augment endogenous glutathione synthesis under circumstances when higher levels may be beneficial

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2020;5:e00071-20

FIGURE 5 Age- and sex-dependent effects of pomegranate extract on TMAO response Although the overall effect of the pomegranate extract on plasma TMAO AUC was null ( P = 0.945), we observed that the participants with increasing TMAO were older (Figure 6A), and in particular the three oldest women ( n = 3

A novel ferroptosis-related biomarker signature to predict overall survival of esophageal squamous cell carcinoma