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identified a novel senescence-associated miRNA, miR-146a, which negatively regulates the NAD/SIRT pathway by directly targeting NAMPT, while AMPK activators such as metformin counteract this process by suppressing miR-146a expression through the IKK/NF-B axis, thereby restoring NAD production and offering a new therapeutic strategy against aging

586 Hypoxia can extensively alter mitochondrial structure, dynamics, and mtDNA stability, leading to impaired respiration, excessive ROS production, increased oxidative damage, and reduced ATP production

Aihara, S

The cryogel platform demonstrates enhanced efficacy against biofilm-associated fungi, and promoting efficient wound healing 20

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