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Many studies have suggested that cancer cells with manifestation of treatment-resistant high-mesenchymal cell state greatly depend on lipid metabolic enzymes which are relevant to the ferroptotic signaling pathway

Negative evidence: A study in Indonesian individuals showed that supplementation with glutathione combined with vitamin C, alpha-lipoic acid, and zinc did not significantly lighten skin compared to placebo (Sitohang et al., J Clin Aesthet Dermatol, 2021) [63]

Funding This study is financially supported by the Open Funds for Shaanxi Provincial Key Laboratory of Infection and Immune Diseases (2023-KFZD-1), the Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory (YKKF2023004), the National Natural Science Foundation of China (Grant No