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doi: 10.1038/s41556-018-0178-0 17 GaoMYiJZhuJMinikesAMMonianPThompsonCBet al

3.4.2 NMDA receptor hypersensitization and subunit remodeling Heavy metals cause NMDA receptors to become overactive in two ways: they directly increase the activity of channels and change the make-up of subunits