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In cohort 3, 16 eyes showed improvement in MMS and heatmaps (Figure 7, AD, and Supplemental Figures 3438, 4046, and 4849) and 2 eyes showed little change or worsening (Supplemental Figures 39 and 47)

Both pyruvate and FAs serve as primary fuel sources in the TCA cycle [146], but -oxidation of FAs generates energy and ROS through the production of acetyl-CoA [147]

~5% of APAP is metabolized via oxidation by the hepatic cytochrome P450 (mainly CYP2E1) into a toxic, highly reactive intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI) *

Osmotic diarrhea may result and is of particular concern in infants

Full exercise recovery benefit by 4-8 weeks