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In line with these results experiments performed with an in vitro human BBB model showed that under hypoxic conditions activation of NRF-2/HIF pathways led to overexpression of P-gp although a distinct expression profile of BCRP was observed [79], while inhibition of HIF-1 can prevent ferroptosis [80]

To evaluate the physiological importance of auxin binding to plant GSTs, the potential inhibitory effects of auxins were examined using different GST isoenzymes expressed in Escherichia coli

Problems arise when nitric oxide production decreases or when the molecule gets broken down too quickly

A randomized study of chemotherapy with cisplatin plus etoposide versus chemo-endocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer in patients in a poor clinical state

Prednisolone or pentoxifylline for alcoholic hepatitis