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Patient registry and longitudinal natural history studyStatus: In progress Natural history is a scientific and systematic study of the patients to understand clinical, biological, and social aspects of the disease

Intravenous (IV) Glutathione is the most effective form , but it does not have FDA approval for skin lightening , and the long-term side effects remain unknown

doi: 10.1007/s11095-013-1007-6

The diarrhoea resolved after 4 days of methylprednisolone treatment

Early research into the bioactivity of ECM fragments focussed on elastin-derived peptides, which exhibit diverse actions against stromal, endothelial and immune cells (Duca et al., 2004), but it is clear that matrikines can be liberated from multiple ECM proteins