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Evidence (excision): A randomized trial that compared narrow margins (1 cm) with wide margins (3 cm) in 612 patients with melanomas no thicker than 2 mm included 359 patients with melanomas measuring 1 mm or less.[1,2][Level of evidence A1] No difference was observed between the two groups in the development of metastatic disease, disease-free survival (DFS), or overall survival (OS)

Chronic treatment with a melanocortin-4 receptor agonist causes weight loss and improves insulin sensitivity in diet-induced obese monkeys. J Clin Endocrinol Metab