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Normal, or healthy, aging is an ill-defined term referring to the natural aging process that is devoid of significant physical or cognitive impairments and allows for the maintenance of subjective well-being (Wong, 2018)

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These particles carry with them a payload of toxic substances, including heavy metals, polycyclic aromatic hydrocarbons, and other carcinogenic compounds that wreak havoc on skin cells

On the other hand, inactivation of CDKN2A gene encoding the tumor suppressor p16INK4a might facilitate escape from senescence in these cells, explaining the association between p16INK4a loss and worse outcomes in PA patients ( Table 2 List of in vitro models developed for preclinical testing