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In 2018, the Newell Laboratory performed sequencing analysis on TILs from a variety of human cancers and reported that the majority of CD8 T cells within tumors are not tumor antigen-specific but instead consist of bystander T cells that recognize unrelated antigens, such as those derived from viruses

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114 In another meta-analysis that pooled findings from eight randomized controlled trials, PNE was found to moderately reduce pain intensity but did not reduce fibromyalgia impact, catastrophizing, or anxiety