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Available epidemiologic evidence indicates a significant synergistic effect between CKD and sarcopenia, making their coexistence a critical risk factor for poor patient prognosis (41, 4749)

doi: 10.1016/j.neuron.2018.11.011 68 KhanS.BarveK

17 Randomized placebo-controlled trials have noted L-arginine, at doses of 1.52.4 grams per day, led to a small but significant positive impact on symptoms in some patients with IC/BPS