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By contrast, beneficial bacteria such as Bifidobacteria and Lactobacillus have low iron requirements [51] and create barriers against pathogen colonization in the gut [39]

Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone

doi: 10.1038/s41419-021-03984-2 68 ZhangLZhangJYeZwMuhammadALiLCulpepperJWet al

Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia

For example, in the male reproductive system, melatonin can inhibit the expression of key steroidogenic genes (such as p450scc, p450c17, and StAR) in Leydig cells via MT1 receptors, thereby reducing testosterone synthesis (66) to inhibit sexual maturation, spontaneous ovulation, and the estrous response (67)