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For instance, in drug target prediction, if the training dataset contains an excess of target data related to a particular disease while having insufficient data for others, the model may predict targets for the data-rich disease more accurately, while predictions for the data-scarce diseases may be biased, thereby impacting the specificity and efficacy of new drug development

GABA Imbalance Alteration of glutamate/GABA equilibrium has been related to a diminished capability to focus on demanding tasks [98] and to result in DA dysregulation, causing inhibition of defective pyramidal neurons and a decrease shift in excitation towards tasks regulated in the PFC [99, 100]

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Altered lipid metabolism contributes to phospholipid degradation, apoptosis, and compromised membrane integrity