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That traceability becomes invaluable later when teams compare data sets, rerun a protocol, or design follow-up assays that build on earlier work

The absence of longitudinal clinical data in FAERS precludes adjustment for these factors

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Cardiovascular effects including changes in blood pressure or heart rate have been studied, with most research suggesting minimal cardiovascular impact, though some studies have noted modest blood pressure reductions in hypertensive individuals, which could be therapeutic rather than adverse

Neuroepidemiology 42:2538 Toth C, Brown MS, Furtado S, Suchowersky O, Zochodne D (2008) Neuropathy as a potential complication of levodopa use in Parkinsons disease