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doi: 10.1016/j.intimp.2023.110312 22 FareauGGVassilopoulou-SellinR

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Results Higher sensitivity to ferroptosis in mesenchymal lung cancer cells In order to examine selective ferroptosis in therapy-resistant mesenchymal cancer cells [9], we used erastin to trigger ferroptosis because a potent analog of erastin, belonging to the group of class I inhibitors targeting XCT is currently undergoing clinical trials for the treatment of cancer [32] due to its in vivo suitable pharmacokinetics, a characteristic not shared by other FINs [33]