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Proline isomerization of histone H3 regulates lysine methylation and gene expression

The pharmacometabolomic approach provided verification of target engagement when using combined treatment with probenecid and NAC in children with severe TBI

From a PPPM perspective, creatine profiling through biofluids, tissue sampling, and advanced imaging (e.g., proton magnetic resonance spectroscopy) offers a minimally invasive approach for early detection, patient stratification, and monitoring of mitochondrial function

doi: 10.1016/j.ejmech.2018.06.053 14 ManachCScalbertAMorandCRmsyCJimnezL